Wolves boss Kenny Jackett will be forced into at least four changes as his side host Walsall in the first round of the Johnstone's Paint Trophy.
The Molineux side are without Sam Ricketts (Wales), Leigh Griffiths (Scotland), Lee Evans and Jake Cassidy (both Wales Under-21s) due to international call-ups.
Full-back Scott Golbourne will be assessed after he was forced off with a back injury on his debut at the weekend.
But Jackett is unlikely to make further changes, with his side enjoying an 11-day rest before their next fixture against Swindon.
Dean Smith is expected to make changes to his Walsall side as they look to return to winning ways following a disappointing 3-0 home league defeat to Preston.
Nicky Featherstone, Romaine Sawyers and Andy Taylor all had to make do with places on the bench for Saturday's loss but could be recalled to Smith's starting XI for the cup clash.
Walsall have not beaten their local rivals in their previous five attempts, drawing one and losing four, and Saddlers boss Smith knows his team will face a difficult test at Molineux.
"We have a quick chance to bounce back at Wolves on Tuesday; it's a tough game but it's a local derby and one that we face with relish," he told the club's official website.