Hartlepool will be without Steve Howard and Antony Sweeney when they host Bradford in the first round of the Johnstone's Paint Trophy Northern Section.
The former Derby striker required stitches to an eye wound after clashing with Torquay's Aaron Downes on Saturday while midfield stalwart Sweeney has been struggling with a calf injury and will not be included in Colin Cooper's plans.
Striker Nialle Rodney will be hoping for his first start of the season after making four appearances from the sub's bench while Andy Monkhouse is also pushing for a place in the starting XI.
Pools boss Cooper will be hoping his misfiring strike force can use the game to kick-start their season after failing to score in all five of their opening Sky Bet League Two games.
Bradford boss Phil Parkinson may call upon Mark Yeates as he continues his rehabilitation from a recent knock.
The Irish-born winger required injections on a knee injury but made a seven minute substitute appearance during the weekend's draw at Stevenage.
Yeates aside, the Bantams boss has no fresh injury concerns but could freshen up his side with the likes of Ricky Ravenhill and Raffaele De Vita both pressing for recalls to the starting XI.
The clash represents a repeat of last year's second round when Bradford needed penalties to see off Hartlepool after both sides played out a goalless draw.