Inverurie Loco's have doubts over the injured trio of Simon Scott, Jack Strachan and Andy Bagshaw as they host an Arbroath side that have lost their last three games on the road.
On a more positive note for the Harlaw Park side Andy Low and Stuart McKay are set to return.
``This will be a really tough test for us as Arbroath can score a lot of goals if you let them get into a rhythm,'' co-manager Scott Buchan said.
``They have had a few disappointing results recently but they are a strong Second Division side and it will take a great performance from our boys to get through.
``We will be well up for the game especially as our game was postponed last week and kick off cannot come quick enough.''
Arbroath have doubts over youngsters Connor Birse and Jake Mair as they head north with goalkeeper Scott Morrison restored to the travelling party after illness saw him miss out last weekend against Ayr United.
Gayfield manager Paul Sheerin said: ``This is a very tricky tie especially with our recent away record so it would be good to have a return to winning ways and get through to the next round.
``I know Inverurie's pitch is a really tight one so it is a game our players will need to roll their sleeves up for and be ready to battle for everything. We went to Keith in similar circumstances last year and won. A repeat of that would be great.``