The stakes could hardly be higher for Piacenza who must already be resigned to Serie B football even if the statistics say they still have a chance.
After 38 minutes, Vittorio Tosto created the home side's first chance when he received the ball and crossed from the left wing to Marco Marchionni who headed the ball goalwards.
Goalkeeper Emanuele Belardi was transfixed but was relieved to watch the ball skim the outside of the post.
Other than that the chances were few and far between in a cagey opening hour, but the game sprang into life midway through the second period.
Reggina's Italy Under-21 striker Emiliano Bonazzoli was the inspiration behind the opener after 67 minutes as he got his head to a cross and headed the ball towards Di Michele who fired his volley inside the near post to the delight of his team-mates.
The visitors from Reggio Calabria were scenting a win that could help them avoid a prompt return to Serie B just 12 months after they had been promoted.
But it only took four minutes for Piacenza to get back in the game with Davide Baiocco putting in a testing cross and Hubner rushing in to head the ball home past a helpless Belardi.
It was Bulgarian Aurelian Patrescu who created the second for Hubner who scored with another textbook header which went in off the underside of the bar.
Hubner, 35, last season finished Serie A's joint top-scorer with David Trezeguet of Juventus on 24 goals, a remarkable achievement from the chain-smoking bar owner who had never played top-flight football until turning 30.
However, goals have been harder to come by this year and his goals look unlikely to save his side this term.
Just as Piacenza fans must have started to believe that another great escape was on the cards, the visitors from Reggio Calabria hit back.
It was a goal made in Latin America as Honduras international Julio Leon crossed the ball to Brazilian Mozart whose header found the corner of the net.
It raised hopes that the south of Italy could still have a club in the Italian top flight next season but with two matches to play Piacenza are five points away from the safety zone and with forthcoming matches against Parma and AC Milan have little reason for optimism.