Unlike their 1-1 draw in their first encounter this season, Capello`s Roma showed their supremacy against a debilitated Piacenza.
A magical first-half by the Giallorossi brought the Stadio Olimpico to life.
Roma`s disappointing departure from the Champions League last week after their 1-1 draw against Ajax has pushed the Giallorossi into ensuring they finish as high as possible in Serie A.
Captain Totti`s official nomination as UNICEF ambassador prior to the clash lifted the talented playmaker.
The Giallorossi came out strongly and rocked Piacenza by taking the lead after just 11 minutes.
Striker Cassano took advantage of Totti`s precision pass and hit the ball low into the right bottom corner, fooling goalkeeper Paolo Orlandoni.
Totti and striker Delvecchio could have increased Roma`s lead minutes afterwards as Piacenza were forced into a rearguard action.
A second goal looked to be coming and it was Delvecchio who got it, getting away from defender Amedeo Mangone and placing the ball again into the right corner, out of the reach of Orlandoni.
Piacenza had a chance to get on the scoresheet four minutes later when Brazilian defender Francisco Lima brought down former Juventus midfielder Enzo Maresca inside the penalty area.
A spot-kick was awarded but the usually reliable Dario Hubner - Piacenza's top scorer with eight goals this season - hit the ball down the middle and Francesco Antonioli made the save.
Totti made it 3-0 two minutes before half-time, collecting a Cassano pass before firing the ball through the legs of Orlandoni.
Piacenza's performance improved in the second half and Marco Marchionni came close to making it 3-1 with a powerful header which Antonioli failed to reach and was relieved to see go over the bar.
The Roma penalty came when Cassano crumpled under a challenge from Orlandoni.
It was a surprise to see Aldair given responsibility, but not so much of a shock when his weak shot towards the left corner was saved by a relieved Orlandoni.
Piacenza remain entrenched in the relegation zone and are now nine points adrift of safety, but coach Luigi Cagni believes there is still a way out of the bottom four.
``Roma are a strong team, if we continue to play like this and improve in defence we can save ourselves,'' he said after the game.
``If we had scored the penalty it would have given us a chance to get back in the game.''
Roma have climbed to eighth place and could still pinch a place in next season's UEFA Cup, even though the Champions League looks beyond them.
Capello had high words of praise for Cassano, who is emerging as an increasingly influential figure.
``Cassano has great quality and we are discovering it now. He is maturing,'' said the Roma boss.
``Antonioli`s [penalty] save was very crucial, although we had plenty of chances to score.''