Michael Coulson was Grimsby`s villain as the free-scoring Mariners drew a blank at Salisbury and will once again need a replay to ensure their FA Cup progression.
Coulson hit the crossbar before the break and wasted a glorious chance to win the second-round tie after half-time as the visitors failed to reproduce the goalscoring form which saw them thrash Stockport 7-0 midweek.
Blue Square Bet South Salisbury may feel their best chance has gone after a spirited display saw them run their Premier opponents close at the Raymond McEnhill Stadium.
Salisbury controlled the first half and could have taken an early lead had Grimsby midfielder Manny Panther not been alert on the line to head clear Daniel Webb's header.
Grimsby rode the early storm and winger Coulson saw an 18-yard drive somehow diverted onto the bar by Brian Dutton.
Then, just before the interval, home keeper Mark Scott was required to tip over Shaun Pearson's powerful header from a corner.
City striker Jake Reid continued to be a menace to Grimsby but the visitors should have scored when Coulson somehow fired over from just five yards with the goal at his mercy after the break.
Reid then fired over for the hosts while Liam Hearn worked hard to forge rare openings at the other end for Grimsby, who will still be confident of progressing having seen off League Two side Port Vale in a first-round replay at Blundell Park.