FC Twente maintained their Eredivisie title challenge as they fought back from a goal down to beat ten-man De Graafschap at De Vijverberg.
De Graafschap, who are rooted to the foot of the table, took an early lead through Soufian El Hassanaoui, but Roberto Rosales and Leroy Fer responded for Twente before the hosts had Rogier Meijer dismissed early in the second half for a second bookable offence.
An upset had appeared on the cards when the home side took the lead with the first genuine attack of the game in just the second minute.
El Hassanaoui received the ball just outside the box and produced a fantastic curling strike to beat Sander Boschker in the Twente goal.
But Twente quickly responded with Rosales and Ola John going close before the former netted a 19th-minute equaliser.
Nacer Chadli set up the chance with an intelligent ball across the box and full-back Rosales was left with a simple finish.
Rosales almost turned provider before the break but Luuk de Jong could only head his superb cross wide, while Willem Janssen missed a simply chance early in the second half.
But the misses did not prove costly as the visitors took the lead in the 52nd minute. Janssen seized on a poor defensive pass to play in Fer to find the net.
Things rapidly got worse for De Graafschap as Meijer saw red just six minutes later having already received a booking for a poor first-half challenge.
Twente then lost De Jong to a knee injury and it seemed to upset their rhythm as they were forced to survive a late rally from their hosts.
First the impressive El Hassanaoui fired narrowly wide before Michael de Leeuw headed over with the goal at his mercy to condemn his side to another defeat.