A hat-trick by Brazilian striker Everton helped Heracles Almelo recover from the fourth-minute dismissal of Mark Looms to post an emphatic win on the road at hapless Willem II.
The rock-bottom hosts took a surprise lead through Andreas Lasnik's penalty after Looms had seen red for a foul on Juha Hakola in the area, but Heracles were level within two minutes through Everton's first.
The Brazilian netted his second after 40 minutes while Willy Overtoom's penalty five minutes later gave the 10 men breathing space at the interval.
Everton completed his treble after 58 minutes, and although Denis Halilovic grabbed a second for Willem II inside the final 10 minutes, further efforts by Overtoom and Kwame Quansah added to the hosts' misery.
Given their awful goal difference, Willem II are effectively six points from even scraping a place in the post-season relegation play-offs, and the manner of this defeat would indicate they are doomed to automatic demotion.
Heracles, meanwhile, are ninth and in striking distance of the Europa League play-off berths.
The hosts got off to a dream start when Hakola was hauled down by Looms inside five minutes. Referee Reinold Wiedemeijer showed no mercy by dismissing the visiting defender, while Lasnik coolly converted the resulting spot-kick.
But with just two wins all season, Willem II seemed to panic after going ahead and within two minutes were pegged back, Overtoom playing in Everton who lashed home low into the right corner.
Everton had another chance on 20 minutes but fired wide, but five minutes before the break he did grab his second when Marko Vejinovic picked him out and the 27-year-old did the rest.
And on the stroke of the interval it was three, Halilovic bringing Everton down in the area and Overtoom tucking the resulting penalty kick into the left corner.
Everton's treble was complete just before the hour, a nice set-play from a free-kick working the ball to the striker who drilled home a low effort from the edge of the box.
Willem II restored some pride when Halilovic nodded in their second on 82 minutes, but Heracles had the final say as Overtoom's shot from distance made it five and Quansah's speculative effort two minutes into added time completed the rout.