Werder Bremen booked their place in the last 32 of the Europa League and extended their unbeaten streak to 22 games with an emphatic 4-1 home triumph over Nacional.
Markus Rosenberg set Thomas Schaaf's side on their way to victory with two goals in three first-half minutes.
A 61st-minute strike from Ruben Micael made the hosts sweat, but Marcelo Moreno restored the two-goal cushion six minutes from time and then Marko Marin completed the rout in stoppage time.
Bremen qualify for the knockout stage along with Athletic Bilbao, who were 3-0 winners at Austria Vienna.
The top two will meet in the final round of group games at San Mames in a fortnight.
Rosenberg put Bremen ahead with just over half an hour played after Moreno had hit the woodwork with his header from Daniel Jensen's corner. The ball fell kindly for Rosenberg, who nodded in his second goal of the season from close range.
Rosenberg doubled his tally three minutes later from a similarly close distance, and from another Jensen corner.
This one was nodded on by Per Mertesacker to the Swede, who could not miss from underneath the crossbar.
Nacional responded well and went close to getting back in the game before the interval with two good chances.
The first was a teasing low cross from Bruno Patacas which went agonisingly close to being converted by both Joao Aurelio and Mateus.
And, just before the half-time whistle, Ruben Micael volleyed just wide of Sebastian Mielitz's goal.
Mielitz was not giving a very comfortable impression on his Bremen debut and he was lucky to get away with a foul on Nejc Pecnic on the hour mark.
Referee Alon Yefet ruled the foul had been committed outside the area and did not even show a yellow card to Bremen's 20-year-old goalkeeper, but justice was done as Ruben Micael sent the direct free-kick inside Mielitz's near post to bring the Portuguese side back into the game.
Mateus came close to an equaliser moments later with a shot from just outside the penalty area, but Mielitz managed to tip the ball over the bar.
Moreno then sealed the win with five minutes to go, heading substitute Marin's cross powerfully past Rafael Bracali for his first goal in Europe.
Marin then completed the scoring deep into stoppage time, converting the rebound after Clemens Fritz's shot had been parried by Bracali.