Stefan Moore bagged his first goal for Kidderminster in a 2-0 win as 10-man Curzon Ashton's FA Cup dream run finally came to an abrupt end in their eighth match.
The former Aston Villa striker poked home in the 38th minute for the Blue Square Premier high-flyers, with Mark Creighton adding a second for Kidderminster after the break.
Curzon, of the UniBond first division north, were far from overawed by the occasion as they played some slick, passing football early on and almost took the lead when Alex Elliott fired inches wide from the edge of the box after 20 minutes.
But their chances were dealt a massive blow in the 30th minute when goalkeeper David Carnell was given his marching orders for bringing down Moore, who had raced on to Matthew Barnes-Homer's flick on.
Martin Brittain curled the resulting free kick inches wide, but Harriers hit the front eight minutes later when Keith Lowe's right wing cross caused confusion in the Curzon ranks and was eventually prodded over the line by Moore.
Harriers made the tie safe after 65 minutes when Creighton towered above the Curzon defence to head Brittain's corner neatly past replacement goalkeeper Denis Barlow.
Curzon pressed bravely in the final 10 minutes, with substitute Glyn Barker enjoying the minnows best chance, but Kidderminster held firm.