Thursday night's trip to France will be a welcome distraction for Real Betis as they get to escape the Primera Division gloom to perform on the stage where they have felt most at home this season.
The Andalusian outfit lie at the foot of the domestic table having won just two games, but are unbeaten in Europa League Group I.
Betis head into the encounter at the Stade Gerland on the back of Sunday's humiliating 4-0 derby loss at Sevilla, which followed their 4-1 defeat to Barcelona and extended their winless run in La Liga to seven games.
``The heavy defeat to Sevilla was a bitter blow for the team,'' Betis goalkeeper Guille Sara said. ``We are all extremely disappointed because we had prepared the game well and we had a lot of expectations.
``Everything went badly and we know we had let ourselves and our fans down.
``I have no doubt that we have enough quality to be higher up in the standings and we just need to turn things around.
``I hope Thursday's game will give us the opportunity to get our confidence back.
``We need to prove to ourselves that we don't deserve to be where we are right now in La Liga.''
Victory at Lyon would not only guarantee Betis a place in the next round but also secure top spot in the pool.
Betis lead the group with eight points, two points clear of second-placed Lyon. Guimaraes are third, two points adrift of Les Gones.
Betis, who held Lyon to a goalless result at home on matchday one, end the group campaign against winless Rijeka at the Estadio Benito Villamarin.
With seven players struggling for fitness, including the team's top scorer Jorge Molina, Betis coach Pepe Mel has included five players from the reserves for the trip to France.
Lyon coach Remi Garde is unlikely to rest players, on the other hand, as they continue their quest to reach the last 32.
Three points against Betis would take Lyon through provided third-placed Guimaraes fail to win at Rijeka - otherwise it will come down to their final group game in Portugal.
``We expect a complicated game on Thursday night,'' Lyon goalkeeper Remy Vercoutre said to www.olweb.fr. ``We know how much this game means for our qualification.''
Lyon go into the match having lost just once in their last seven games and on the back of Saturday's 1-1 draw against Valenciennes, which kept them seventh in Ligue 1.