Carlisle boss Greg Abbott will be without the services of striker Lee Miller for their Capital One Cup tie against Blackburn.
Miller was shown a straight red card during their opening-day defeat to Leyton Orient and begins a three-match ban.
Abbott is also likely to be without defender Sean O'Hanlon who missed out on Saturday with a knee problem.
Midfielder Matty Robson could also be absent again as he continues to struggle with a back injury.
Blackburn forward Ruben Rochina isa definite absentee.
Rochina may be out for up to 12 weeks after dislocating his shoulder during Sunday's 1-1 draw at Derby.
Fellow striker Leon Best is expected to deputise having equalised after coming on as a substitute at Pride Park.
Rovers are aiming to avoid successive defeats to League One opposition after losing to MK Dons in the second round last season.