It was later confirmed that Messi will not feature tomorrow night as he continues to recover from a thigh strain.
The Barcelona striker missed the club's final pre-season game against a Malaysia XI on Saturday and it has now been confirmed he will return to Catalunya to work on his recovery.
A statement on fcbarcelona.com read: ``Leo Messi will not feature in the international friendly between Argentina and Italy in Rome this Wednesday.
``After undergoing tests conducted by the Argentina national team doctors, it was decided that Messi should return to Barcelona and focus on recovering from his muscle injury.
``The injury forced the forward miss out on Barca's last match of the Asia Tour.''