Fenerbahce coach Aykut Kocaman believes Lazio are ``one step ahead'' in the race to lift this season's Europa League trophy.
The Turkish giants are looking to reach the last four of a UEFA competition for the first time by ousting Lazio at the quarter-final stage.
Vladimir Petkovic's Biancocelesti, however, are the only side yet to lose a game in this season's Europa League and are also the highest scoring club with 19 goals.
Fener may have dominated Group C before knocking both BATE Borisov and Viktoria Plzen out but Kocaman knows conquering the Romans at the Sukru Saracoglu Stadium will be a tall order.
He told fenerbahce.org: ``Of all the teams competing in the Europa League this season, Lazio just seem to be one step ahead of the rest.
``It will be an extremely challenging game and one that is so valuable to us. Therefore, playing as a team will be crucial and we will have to score.''
Former Liverpool duo Raul Meireles and Dirk Kuyt should start with ex-Chelsea midfielder Miroslav Stoch pushing for inclusion in the first XI.
Biancocelesti striker Miroslav Klose, meanwhile, returned from a leg injury against Catania on Saturday and could partner either Louis Saha or Libor Kozak.
The Czech Republic international is now the tournament's top scorer after his hat-trick against Stuttgart in the last 16 moved him on to eight goals, one ahead of Napoli's Edinson Cavani.
For visiting coach Petkovic, the Sukru Saracoglu holds special memories of a 1-0 win he described as ``probably my greatest victory ever''.
His Young Boys side eliminated Kocaman's Fenerbahce from the third qualifying round of the 2010-11 Champions League by winning in Istanbul having claimed a 2-2 draw in Berne.
And on his return to Turkey, he told Gazzetta.it: ``I know Fenerbahce well - they are a very worthy opponent.
``In this stadium and with these fans they'll always have a small advantage. We will need to harness all of our mental strength to dominate them.''