After a comfortable 4-0 victory in Austria Bayer Leverkusen will be widely expected to thrash Rapid Vienna again in the return fixture.
However, Leverkusen manager Sami Hyypia, the former Liverpool defender, is taking nothing for granted and warned his side they cannot let their standards slip.
``Of course we want to win, but nobody should think it will be easy after the score in the first game,'' he said.
``It's another game where we have to refocus. It will be difficult if we do five or 10 per cent less.''
Experienced centre-back Manuel Friedrich added: ``What you've done in the past doesn't count for anything in football.
``We're starting at 0-0 again. We need to be alert and focussed and impose ourselves on Vienna.''
Bayer, currently fourth in the Bundesliga, top Group K on goal difference from Metalist Kharkiv and both clubs will be through to the last 32 if they win. The Ukrainians are at home to Rosenborg.
Rapid are the only one of 48 teams in the Europa League yet to secure a point in this season's competition, while Bayer and Newcastle are the only sides who have not conceded a goal in the group stage so far.
New left-back Sebastian Boenisch is not an option for the home side. His signing was announced on Sunday, but he is not entitled to play in the Europa League in 2012 as he was not registered as a transferred player by UEFA when the transfer window closed on August 31.
Rapid's record in Germany over the years does not bode well either - it reads eight games, eight defeats - yet around 3,200 of their fans are expected to make the journey to the BayArena.