Tongo Doumbia, Dave Edwards and Stephen Hunt could be back in the frame for Wolves' home clash against Blackpool.
The midfield trio have all returned to training and will provide a huge boost as Wanderers go in search of their first win under boss Dean Saunders, who also has no new injury or suspension concerns to contend with.
Doumbia has missed the last four games with a hamstring injury and could well make Saunders' matchday 18.
Edwards (hamstring) and Hunt (hip), however, are returning from more long-term absences and it remains to be seen whether they are deemed ready for match action.
Bjorn Sigurdarson was back on the bench for last weekend's goalless draw at Sheffield Wednesday after a thigh injury and will again be involved.
Razak Boukari is on the comeback trail is expected to return to training in around three weeks but Steven Mouyokolo, Wayne Hennessey and George Elokobi remain sidelined.
Blackpool caretaker manager Steve Thompson will have a fuller squad to choose from when he takes the reins once more.
Pool's first team was decimated by illness on the eve of last weekend's 2-1 defeat to league leaders Cardiff.
Full-backs Stephen Crainey and Neal Eardley, captain Alex Baptiste and veteran striker Kevin Phillips were all struck down and missed out but are available once more to face Dean Saunders' side.
The Seasiders' two long-term injury victims have suffered mixed fortunes in recent weeks.
Winger Matt Phillips was named among the substitutes against Cardiff given the depleted nature of Thompson's squad and marked his return from a toe problem with a late cameo.
But centre-back Ian Evatt is set to miss the rest of the season after undergoing knee surgery.