Valencia's good form continued as they held struggling Sevilla to a 0-0 draw in La Liga on Sunday.
Los Che had won their previous three games and, although they could not continue that run, it was another point gained.
Sevilla look safe in fourth place, but have gone off the boil and now sit three points behind Atletico Madrid after only one win from their last seven league games.
Espanyol's Leo Baptistao scored a brilliant injury-time winner to see off relegation-threatened Leganes.
The Brazilian, a second-half substitute, collected the ball from Hernan Perez with seconds left on the clock and produced a sublime lobbed finish to seal a 1-0 win.
Defeat leaves Leganes one place above the bottom three, while Espanyol moved up to ninth to stay within touching distance of the Europa League slots.
Victory at Estadio Municipal de Butarque is a third win in four games for Quique Sanchez Flores' side.
Real Betis climbed up to 14th place with a 2-0 victory over Eibar.
The goals came at either end of the game, with Jonas Martin heading in Rafael Navarro's cross in only the second minute.
They wrapped up the points a minute from time with a breakaway goal finished off by Dani Ceballos.
The defeat ended a three-game winning run for Eibar and was a blow to their hopes of securing European football for next season.
Tony Adams' first match in charge of Granada ended in a 3-0 defeat against a second-string Celta Vigo.
The former England defender took over the hotseat for the strugglers earlier this week following the dismissal of Lucas Alcaraz and admitted they need a miracle to stay up.
But there was no sign of that occurring on Sunday as Jozabed's first-half goal and second-half efforts from Marcelo Diaz and Claudio Beauvue clinched victory for Celta.
It looked a golden chance for Granada to take something from the game, with Celta making 10 changes in preparation for Thursday's Europa League quarterfinal second leg against Genk.