All kick-off times in GMT.
- « Previous Day |
- Sat, May 25, 2013
- | Next Day »
| 23:00 | DC United | v | Portland Timbers |
| 23:00 | Montreal Impact | v | Philadelphia Union |
| 23:30 | New England | v | Toronto FC |
| May 26, 00:30 | FC Dallas | v | San Jose |
| May 26, 01:00 | Colorado | v | Chivas USA |
| May 26, 01:00 | Real Salt Lake | v | Chicago |
| TBD | TBD | v | TBD |
| 51' | CR Vasco da Gama | 1 - 0 | Portuguesa de Desportos |
| 53' | EC Vitória | 2 - 1 | Internacional |
| May 26, 00:00 | Corinthians | v | Botafogo |
| FT | Ñublense | 2 - 4 | Audax Italiano |
| FT | Cobreloa | 2 - 0 | Santiago Wanderers |
| FT | Cobresal | 3 - 2 | Antofagasta |
| FT | O'Higgins | 0 - 1 | Unión La Calera |
| 23' | Huachipato | 0 - 0 | Palestino |
| May 26, 00:30 | Everton CD | v | Municipal Iquique |
| FT | Fénix | 1 - 1 | Danubio F.C. |
| FT | Progreso | 2 - 3 | Nacional |
| FT | Racing (U) | 0 - 0 | Liverpool |
| FT | River Plate | 5 - 0 | Central Español |
| 23:15 | El Tanque Sisley | v | Wanderers |
| FT | Itagüí | 3 - 0 | Boyacá Chicó FC |
| 8' | Independiente Santa Fe | 1 - 0 | Cúcuta Deportivo |
| May 26, 00:45 | Atlético Junior | v | La Equidad |
| FT | Deportivo Capiatá | 0 - 2 | Cerro Porteño |
| May 26, 02:00 | Herediano | v | Cartagines |
| 23:00 | Boston Breakers | v | Washington Spirit |
| May 26, 00:35 | FC Kansas City | v | Sky Blue FC |
| May 26, 02:00 | Seattle Reign FC | v | Portland Thorns FC |