All kick-off times in GMT.
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- Wed, Jun 19, 2013
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| Jun 20, 00:00 | Montreal Impact | v | Houston |
| Jun 20, 00:30 | Chicago | v | Colorado |
| Jun 20, 02:00 | Vancouver Whitecaps | v | Chivas USA |
| Jun 20, 02:30 | Los Angeles | v | Portland Timbers |
| HT | Talleres de Córdoba | 1 - 0 | Newell's Old Boys |
| 21:30 | Atletico Rafaela | v | San Lorenzo |
| 23:30 | All Boys | v | Boca Juniors |
| Group A | |||
|---|---|---|---|
| Jun 20, 00:10 | Independiente Santa Fe | v | Millonarios |
| Jun 20, 01:10 | Once Caldas | v | Deportivo Cali |
| FT | Sport Huancayo | 4 - 1 | José Gálvez |
| FT | León de Huánuco | 1 - 0 | Real Garcilaso |
| 8' | Juan Aurich | 0 - 0 | Universitario de Deportes |
| 23:00 | San Martin | v | César Vallejo |
| Jun 20, 01:00 | Alianza Lima | v | Sporting Cristal |
| FT | General Díaz | 1 - 0 | Sp. Carapeguá |
| FT | Deportivo Capiatá | 1 - 1 | Sol de América |
| FT | Rubio Ñú | 1 - 0 | Nacional |
| 22:30 | Guaraní | v | Cerro Porteño |
| 22:30 | Sportivo Luqueño | v | Cerro Porteño de Franco |
| Jun 20, 00:00 | Manta F.C. | v | Emelec |