All kick-off times in GMT.
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- Sat, May 25, 2013
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| 23:00 | DC United | v | Portland Timbers |
| 23:00 | Montreal Impact | v | Philadelphia Union |
| 23:30 | New England | v | Toronto FC |
| May 26, 00:30 | FC Dallas | v | San Jose |
| May 26, 01:00 | Colorado | v | Chivas USA |
| May 26, 01:00 | Real Salt Lake | v | Chicago |
| TBD | TBD | v | TBD |
| 21:30 | CR Vasco da Gama | v | Portuguesa de Desportos |
| 21:30 | EC Vitória | v | Internacional |
| May 26, 00:00 | Corinthians | v | Botafogo |
| FT | Ñublense | 2 - 4 | Audax Italiano |
| 25' | Cobreloa | 0 - 0 | Santiago Wanderers |
| 1st | Cobresal | 2 - 0 | Antofagasta |
| 29' | O'Higgins | 0 - 0 | Unión La Calera |
| 22:15 | Huachipato | v | Palestino |
| May 26, 00:30 | Everton CD | v | Municipal Iquique |
| 2nd | Fénix | 1 - 1 | Danubio F.C. |
| 91' | Progreso | 2 - 2 | Nacional |
| 2nd | Racing (U) | 0 - 0 | Liverpool |
| 2nd | River Plate | 5 - 0 | Central Español |
| 23:15 | El Tanque Sisley | v | Wanderers |
| 2' | Itagüí | 0 - 0 | Boyacá Chicó FC |
| 22:30 | Independiente Santa Fe | v | Cúcuta Deportivo |
| May 26, 00:45 | Atlético Junior | v | La Equidad |
| 72' | Deportivo Capiatá | 0 - 1 | Cerro Porteño |
| May 26, 02:00 | Herediano | v | Cartagines |
| 23:00 | Boston Breakers | v | Washington Spirit |
| May 26, 00:35 | FC Kansas City | v | Sky Blue FC |
| May 26, 02:00 | Seattle Reign FC | v | Portland Thorns FC |