All kick-off times in GMT.
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- Fri, Feb 15, 2013
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| FT | SC Paderborn 07 | 2 - 0 | FC Erzgebirge Aue |
| FT | SSV Jahn Regensburg | 0 - 1 | TSV Eintracht Braunschweig |
| FT | TSV 1860 Munich | 0 - 1 | VfL Bochum |
| FT | Ajaccio GFCO | 2 - 3 | Nimes |
| FT | Arles | 0 - 1 | Niort |
| FT | FC Istres | 0 - 3 | AJ Auxerre |
| FT | Le Havre AC | 2 - 1 | Angers |
| FT | Le Mans | 1 - 1 | Caen |
| FT | Lens | 4 - 3 | Chateauroux |
| FT | Stade Laval | 3 - 0 | Sedan |
| FT | Tours | 2 - 1 | Clermont Foot |
| FT | Akhisar Belediye | 1 - 2 | Galatasaray |
| FT | Deportivo Quito | 3 - 1 | El Nacional |
| FT | LDU Quito | 1 - 2 | Emelec |
| FT | Club Deportivo Cuenca | 1 - 1 | Deportivo Quevedo |