All kick-off times in GMT.
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- Sat, May 25, 2013
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| 23:00 | DC United | v | Portland Timbers |
| 23:00 | Montreal Impact | v | Philadelphia Union |
| 23:30 | New England | v | Toronto FC |
| May 26, 00:30 | FC Dallas | v | San Jose |
| May 26, 01:00 | Colorado | v | Chivas USA |
| May 26, 01:00 | Real Salt Lake | v | Chicago |
| May 26, 02:00 | Herediano | v | Cartagines |