All kick-off times in GMT.
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- Sat, May 25, 2013
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| 23:00 | DC United | v | Portland Timbers |
| 23:00 | Montreal Impact | v | Philadelphia Union |
| 23:30 | New England | v | Toronto FC |
| May 26, 00:30 | FC Dallas | v | San Jose |
| May 26, 01:00 | Colorado | v | Chivas USA |
| May 26, 01:00 | Real Salt Lake | v | Chicago |
| TBD | TBD | v | TBD |
| 21:30 | CR Vasco da Gama | v | Portuguesa de Desportos |
| 21:30 | EC Vitória | v | Internacional |
| May 26, 00:00 | Corinthians | v | Botafogo |
| 16:30 | Ñublense | v | Audax Italiano |
| 20:00 | Cobreloa | v | Santiago Wanderers |
| 20:00 | Cobresal | v | Antofagasta |
| 20:00 | O'Higgins | v | Unión La Calera |
| 22:15 | Huachipato | v | Palestino |
| May 26, 00:30 | Everton CD | v | Municipal Iquique |
| 18:30 | Fénix | v | Danubio F.C. |
| 18:30 | Progreso | v | Nacional |
| 18:30 | Racing (U) | v | Liverpool |
| 18:30 | River Plate | v | Central Español |
| 23:15 | El Tanque Sisley | v | Wanderers |
| 20:15 | Itagüí | v | Boyacá Chicó FC |
| 22:30 | Independiente Santa Fe | v | Cúcuta Deportivo |
| May 26, 00:45 | Atlético Junior | v | La Equidad |
| 19:00 | Deportivo Capiatá | v | Cerro Porteño |
| May 26, 02:00 | Herediano | v | Cartagines |
| 23:00 | Boston Breakers | v | Washington Spirit |
| May 26, 00:35 | FC Kansas City | v | Sky Blue FC |
| May 26, 02:00 | Seattle Reign FC | v | Portland Thorns FC |