Real Madrid have been drawn against Segunda Division B side Ponferradina in the last 32 of the Copa del Rey.
Real were knocked out by third-tier sides in successive years at this same stage of the competition in 2009 and 2010, losing to Real Union and Alcorcon, before bouncing back to win the cup under Jose Mourinho last season.
Cristiano Ronaldo's extra-time goal meant Real beat Barcelona 1-0 in the final to earn their 18th Copa del Rey crown - their first since 1993 and since Mourinho joined from Inter in 2010.
Ponferradina, relegated from the second division last season, are currently fourth in Spain's Segunda Division B Group 2 - the same level at which Real's reserve team compete.
Ponferradina president Jose Fernandez, who is a Madrid member, was quoted as saying on the Real website: "This is something to be proud of and we are. It's the opponent that we wanted and we've got them. To see Jose Mourinho's team play at Ponferrada is double reason to be happy.''
Barca, who boast a record of 25 Copa del Rey trophy wins following their success in 2009, are also facing third-tier opposition in their two-legged last-32 tie in the form of L'Hospitalet, who are in Segunda Division B Group 3.
In selected other matches, 2010 winners Sevilla face San Roque de Lepe, 23-times Copa champions Athletic Bilbao take on Real Oviedo, Valencia meet Cadiz and Villarreal face Mirandes.
Alcorcon, who embarrassed Real two years ago by beating them 4-0 in the first leg of their last-32 tie en route to a 4-1 aggregate victory, take on top-flight Real Zaragoza.
In four all-Primera Division encounters, Racing Santander face Rayo Vallecano, Getafe take on Malaga, Real Sociedad meet Granada and Real Mallorca were paired with Sporting Gijon.
The first leg of the matches will be played between December 9-13, with the return legs scheduled for December 21.
Full draw: Cadiz v Valencia, L'Hospitalet v Barcelona, Ponferradina v Real Madrid, Mirandas v Villarreal, San Roque de Lepe v Sevilla, Albacete v Atletico Madrid, Real Oviedo v Athletic Bilbao, Almeria v Osasuna, Alcorcon v Real Zaragoza, Celta de Vigo v Espanyol, Cordoba v Real Betis, Deportivo La Coruna v Levante, Real Mallorca v Sporting Gijon, Racing Santander v Rayo Vallecano, Getafe v Malaga, Real Sociedad v Granada.