Arsene Wenger expects Abou Diaby to be absent for "over three weeks" after the Arsenal midfielder sustained a calf strain in Wednesday's 2-2 draw with Wigan.
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Diaby was handed his first start since October but lasted only 27 minutes of the game at the DW Stadium before succumbing to another fitness problem.
Wenger expects to be without the France international for a number of weeks, while long-term injury victims Thomas Vermaelen and Manuel Almunia remain unavailable.
"We lost Diaby last night for a while and he will have a scan today [Thursday] but in my opinion he will be out for over three weeks," Wenger told the club's official website. "Of course Thomas Vermaelen is not back, Manuel Almunia is still injured and Kieran Gibbs is injured as well with his ankle. He is not back but everybody else should be available."
Wenger has also provided an update on the fitness of young midfielder Emmanuel Frimpong, who starred in pre-season before suffering a cruciate ligament injury.
"He is coming along well for a guy who has a cruciate," Wenger said. "You count nine months and it is now nearly six. He is close to running and in one month he should start to play in training."