Alfredo Ramua's 87th minute strike gave Peruvian side Real Garcilaso their first ever victory in the Copa Libertadores with a 1-0 win over Paraguay's Cerro Porteno in Group 6.
The hosts controlled possession for most of the match, but were unable to trouble the scoresheet. With three minutes to go, a fast counter-attack from Real Garcilaso ended with a shot on goal that keeper Diego Barreto could only parrie away. Ramua took the loose ball on the other side of the box and slotted home for the winner.
Elsewhere in Group 6, Santa Fe and Tolima drew 1-1 in an all-Colombian duel. Andres Andrade put Tolima ahead just four minutes into the game, only for Santa Fe to equalise just short of the quarter-hour mark through a powerful John Valencia free-kick.
In Group 7, Deportivo Lara beat Argentinian side Newell's Old Boys 2-1 in Venezuela. Jesus Gomez put the hosts ahead only six minutes into the game after taking advantage of a ball that deflected off defender Pablo Perez, giving him a clear sight of goal.
Early in the second half, Lara struck again, doubling the advantage with a powerful shot by Marlos Fernandez.
Newell's kept looking for their goal, but they could only achieve a consolation in the 91st minute, through Marcos Caceres.
In Group 2, Paraguayan side Libertad claimed a valuable 2-0 win at Argentina's Tigre. After a goalless first half, Libertad gained the ascendency in the 53rd minute.
Tigre's Alejandro Donatti handled in the box and was sent off, leaving Sergio Aquino to convert from the spot. With the numerical advantage, Libertad controlled the rest of the game and Jorge Gonzalez sealed the victory with a free-kick three minutes before the final whistle.
Information from the Press Association was used in this report.