Tijuana have sealed second place in the Apertura table with a 2-0 win at Guadalajara.
Tijuana needed to overturn a five-goal deficit in goal difference to finish top heading into the play-offs, and got off to the perfect start with two goals in the first two minutes from Alfredo Moreno and Duvier Riascos, did not find the net again and the win had to be content with second, sandwiched between Toluca and Leon.
Meanwhile Unam Pumas beat Atlante 3-2 but they still missed a play-off spot.
Either side could have snuck into the play-offs with a big win and it was Atlante who started brightest, Esteban Paredes putting them ahead in thefifth minute, but goals from Luis Fuentes and Marco Palacios turned the game before half-time.
Palacios then put the ball in his own net after 51 minutes, before Martin Bravo sealed a win for the Pumas which ultimately proved academic.
Elsewhere Queretaro won 1-0 at Puebla with Luis Landin scoring the winner.
The play-offs begin next weekend with the first of two legs of the quarter-final matches.
Information from the Press Association was used in this report