Sevilla's reliance on the goals of Alvara Negredo cost them as they made all the running but were held to a frustrating 0-0 draw at home to Levante.
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The former Real Madrid forward had scored half of the Rojiblancos 12 league goals, and with him unable to fire they had to settle for a point.
Negredo could not be blamed entirely - he was part of a forward line which failed to break down Juan Ignacio Martinez's side - but it will be of concern that if he does not score, Sevilla do not look as great a threat. Their effort could not be faulted, but their execution left a lot to be desired.
Aritz Aduriz's first-half brace ensured Athletic Bilbao ended their recent dismal run of form with their first away win of the season, 2-1 at fellow strugglers Granada.
Aduriz opened the scoring from the penalty spot in the 13th minute and then doubled the visitors' lead in the 27th minute with a fantastic strike. Although Youssef El Arabi pulled one back eight minutes after the interval, Bilbao held on to halt a run of three successive defeats in all competitions.
It helped Los Leones move away from the drop zone and boss Marcelo Bielsa will be hoping the win can kickstart their season.
Deportivo La Coruna got their first win since the opening game of the season as Bruno Gama's fine individual goal was enough to see off Mallorca 1-0 at the Riazor.
The Portuguese winger was a threat to the visitors' defence all afternoon and showed great skill to open up a shooting chance for himself before firing low past Dudu Aouate in the 30th minute.
Gama and Pizzi also hit the woodwork for the hosts in the second half but despite a late flurry of long-range efforts from Mallorca they held on to move out of the bottom three.
Diego Colotto's first goal for Espanyol handed the Catalans their first away win of the campaign and moved them out of the relegation zone for the first time this season as they beat Real Sociedad 1-0.
It was the home side who carried the greater threat for the first hour as Imanol Agirretxe was denied by a goal-line clearance by Sergio Garcia and Asier Illarramendi saw a spectacular 30-yard volley turned over by Cristian Alvarez.
However, the Basques were made to pay for their profligacy in front of goal and were hit with a sucker punch 12 minutes from time as Colotto was on hand to tap home after Hector Moreno had kept the ball alive from Joan Verdu's corner.
A fourth loss in five games had the home fans calling for manager Philippe Montanier's resignation by the final whistle, but in truth defeat was harsh on his side who missed the invention of top-scorer Antoine Griezmann due to a muscle injury.
Ten-man Osasuna remained rooted to the foot of the table after Patrick Ebert's late goal handed Valladolid a 1-0 win at El Sadar.
Kike Sola had wasted a guilt-edged chance to put the hosts ahead with 18 minutes remaining but the game swung in the visitors' favour three minutes later when Ruben Gonzalez was sent off after collecting a second yellow card.
And Valladolid took full advantage as a rapid counter-attack from an Osasuna corner saw Ebert go through on goal and he took his time before chipping the ball beautifully over Andres Fernandez for his second goal in two games.
More to follow...