Bayern Munich hope to end their poor run at Hamburg, where they have not won since November 2006, when the two clubs meet on Saturday night.
A big task awaits the Bundesliga leaders, who face a side in much-improved form and now close to the Europa League places.
Extra pressure could be piled on them if closest chasers Schalke, who kick off at Hoffenheim earlier in the day, have won to close the gap to just one point.
But Bayern director of football Matthias Sammer said: "I don't have the feeling we have to care about what other teams do. It does not matter if the gap is down to one point, as we know what we are able to do - and that is a lot."
Thomas Muller, who has never tasted victory at Hamburg, said he was keen to end that run, adding: "Over the past few years, it has been very difficult for us at Hamburg. Therefore, I want to finally win there. That is our aim."
Arjen Robben, who captained Bayern in their 4-0 win over Kaiserslautern in the DFB Pokal, said: "We must remain calm but also be focused in every game."
Bayern coach Jupp Heynckes rested some first-team regulars in the cup game, but star players Bastian Schweinsteiger, Manuel Neuer, Philipp Lahm and Toni Kroos are all set to return at Hamburg.
It is also likely that Franck Ribery, who missed the home defeat to Leverkusen through injury, will return.