Uruguayan giants Nacional made it into the Copa Sudamericana second round as they hammered Chile's Iquique 4-0 in the second leg of their tie.
Nacional, coached by Gustavo Diaz, progressed in the tournament thanks to a 4-2 aggregate triumph at the Estadio Centenario in Montevideo.
Alexis Rolin put Nacional ahead in the sixth minute with a header, before Gonzalo Bueno doubled the lead from close range just before the interval after good work by Alexander Medina.
In the 83rd minute, Iquique midfielder Ruben Taucare was sent-off after a foul and Alvaro Recoba turned that free-kick close to the box into Nacional's third goal.
The win was wrapped up in injury-time when Matias Vecino netted, seconds after midfielder Santiago Romero was dismissed to even the numbers up.
"We maybe felt tired in the second half because we tried to impose our speed in the first," Recoba told Fox Sports.
"Iquique were tough rivals and we may have a better squad on paper, but we had to show it on the field. I think we won deservedly."
Ecuador's Liga de Loja or Monagas of Venezuela will be Nacional's next rivals. The duo meet on Thursday with Liga de Loja 2-0 up after the first leg.
In Colombia, hosts Millonarios booked a berth in the next round thanks to a 3-0 victory over Inti Gas Deportes of Peru.
Having drawn 0-0 in the first match, Wilberto Cosme put Millonarios ahead in the 36th minute by heading a Lewis Ochoa cross into the net.
Harrison Otalvaro set up Wason Renteria to make it 2-0 in the 72nd minute, then scored himself in the last minute of the game, as the 2007 semi-finalists set up a tie against Paraguay's Guarani for a place in the round of 16.
In Uruguay, Cerro Largo played out a goalless draw with Bolivia's Aurora, who progressed thanks to their 2-1 first leg win.