Burton Albion progressed to the Capital One Cup second round with a shock 5-2 penalty shoot-out victory over Sheffield United at Brammall Lane.
Danny Wilson's side crash out after twice falling behind to their League Two opponents as the match finished 2-2 in normal time.
Steve Bruce began his reign as Hull manager in dramatic fashion as the Tigers secured a penalty shoot-out victory following a 1-1 draw with Rotherham.
The Championship side had to come from behind after summer signing Lionel Ainsworth made an immediate impact from the bench, putting Rotherham ahead in the 52nd minute with an unstoppable volley from the edge of the box. Bruce's own super sub Aaron Mclean spared his blushes with an equaliser after 70 minutes.
Mark Bradley missed in the shoot-out with the 14th spot-kick, his effort coming back off the crossbar as Hull emerged victorious.
Stale Solbakken started life as Wolves boss with an unconvincing victory after his side just about edged past Aldershot 7-6 on penalties at Molineux.
Solbakken's side, who are bidding to secure an immediate return to the Premier League, were desperately short of quality.
Sylvan Ebanks-Blake opened the scoring in the second half before the League Two visitors, who made the fourth round last term before bowing out to Manchester United, quickly levelled matters through Michael Rankine's header.
And after both sides were put through a draining 120 minutes on the opening day, it was left for Wanderers keeper Carl Ikeme to make the decisive shoot-out save to deny Jordan Roberts from the spot and seal a narrow 7-6 triumph.
Neil Warnock's new-look Leeds cruised past Shrewsbury with a 4-0 win in the first round as goals from Luciano Becchio, summer signings Luke Varney and David Norris and Ross McCormack's penalty secured an easy win.
Tony Mowbray's new-look Middlesbrough secured their spot in the second round of the Capital One Cup thanks to a 2-1 victory over Bury at Gigg Lane.
A side containing five new faces eased past their npower League One opponents thanks to goals from Marvin Emnes and debutant Emmanuel Ledesma.
Substitute Chris Iwelumo's extra-time goal secured a 1-0 victory over Wycombe for Gianfranco Zola in his first competitive game in charge of Watford.
Two goals from Max Clayton helped Crewe Alexandra to a 5-0 win over Hartlepool at Gresty Road.
Ajay Leitch-Smith and Mathias Pogba were also on target for the Railwaymen before half-time while Pogba added another in the final minute to make it five.
A first-half strike by winger Matty Robson enabled Carlisle to see off a determined challenge from League Two side Accrington Stanley as the Cumbrians held out for a 1-0 win.
Summer signing Ashley Hemmings scored on his debut to send Walsall into the second round with a 1-0 win at home to 10-man Brentford.
Chris Dagnall spared team-mate Ben Alnwick's blushes by firing Barnsley to a 4-3 win over Rochdale after extra-time at Spotland.
James Hanson's stunning extra-time strike took Bradford to a shock 1-0 victory over a rusty Notts County in the first round at Meadow Lane.
Super-sub Ryan Lowe struck the winning penalty as MK Dons stuttered through their opening tie at Cheltenham with a 5-3 shoot-out success.