Liverpool have announced that director of football Damien Comolli has left the club by "mutual consent".
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Comolli first arrived at Liverpool in November 2010, initially working as a director of football strategy before his role was redefined in March last year.
During his time at Anfield, the club made a number of big-money signings, including Andy Carroll (£35 million), Jordan Henderson (£16 million) and Stewart Downing (£20 million), but he will now depart after a disappointing campaign in the Premier League.
"I am grateful to have been given the opportunity to work at Liverpool and am happy to move on from the club and back to France for family reasons," Comolli told the club's official website. "I wish the club all the best for the future."
Principal owner John Henry said: "We are grateful for all of Damien's efforts on behalf of Liverpool and wish him all the best for the future."
Liverpool chairman Tom Werner added: "The club needs to move forward and we now have a huge game on Saturday. It is important that everyone joins us in supporting the manager and gets behind Kenny and the team and focuses on a strong finish to the season."
Comolli, who had previously worked at clubs including St Etienne, Arsenal and Tottenham, also helped the Reds to sign the likes of Luis Suarez, Craig Bellamy and Jose Enrique, and Kenny Dalglish is grateful for his efforts in securing targets.
"I had a fantastic working and personal relationship with Damien since he came here," Dalglish said. "It is disappointing but I suppose there is not much in football which comes as a surprise.
"He has been really helpful in every transfer target we've gone for. Everyone who has come into the club since Damien has been here was of my choice. Once I made the choice who I wanted, Damien went away and did a fantastic job of bringing them in.
"It is sad to see anyone leave the football club and he goes with my best wishes and hopefully it is not long before we meet again. We wish him well with everything that he does."
Meanwhile, the club also confirmed that Head of Sports Medicine and Sports Science, Dr Peter Brukner will leave by the end of the season.
Managing Director Ian Ayre said: "We are grateful to Peter who has been the catalyst for the transformation of our Sports Medicine and Sports Science capability at the Club since he joined two years ago. He has been instrumental in re-defining our requirements and bringing first class people into the team, providing us with a great platform to move forward. We wish him all the best for the future."
Dalglish added: "The framework Peter has established has allowed us to see some very real results in relation to our overall levels of fitness and a reduction in injury levels. Peter acted as the key advisor to the club in this regard, and we wish him well in the future."
While Brukner himself commented: "It has been an honour to work at Liverpool Football Club. I am very proud of what we have achieved over the past two years, as can be seen by the reduced injury rate and improved fitness levels. With a world class staff now in place, I feel I have accomplished what I was asked to do by LFC in 2010 and the Club is in good hands. I wish the Club every success in the future."
Liverpool are currently eighth in the table, 13 points behind Tottenham and Newcastle, though they have won the Carling Cup and face Everton in the FA Cup semi-finals.