Spurs and Chelsea victorious
Gareth Bale continued his sparkling recent form for Tottenham with a sublime free-kick to open the scoring against Lyon.
As on so many occasions throughout the season, Bale rescued Tottenham in their Europa League tie with Lyon, scoring a last minute winner.
Oscar's goal proved the difference between Chelsea and Sparta Prague as the Blues won 1-0.
Pepe Reina made some excellent saves for Liverpool but was ultimately beaten twice as Zenit recorded a 2-0 win.
Papiss Cisse had two goals controversially disallowed for Newcastle during their 0-0 draw with Metalist.
Rodrigo Palacio was the main man for Inter, scoring twice as they saw off Cluj 2-0 to grab a healthy first leg advantage.
Napoli keeper Morgan De Sanctis had to fish the ball out of his net three times as his side lost 3-0 to Viktoria Plzen.
Oscar Cardozo grabbed his third European goal of the season as Benfica won 1-0 at Bayer Leverkusen.