David Moyes lost to his old club as Everton made history at Old Trafford.
Liverpool's title challenge was dealt a blow as they lost 3-1 at Hull.
Aaron Ramsey inspired Arsenal to victory at his old club to send the Gunners seven points clear.
A tribute to Manchester United legend Ryan Giggs, who reached another landmark on November 29, 2013.
Wayne Rooney put in a superhuman shift to lead Manchester United to a rout over Leverkusen, while Bayern remained unbeaten.
Arsenal eased past Marseille while Dortmund claimed a crucial win. Barca were shocked by Ajax and Milan trounced Celtic.
Arsenal and Chelsea collected three points while Everton and Liverpool played out a six-goal thriller.
Chelsea salvaged a draw with West Brom thanks to a dubious penalty decisioin, while Liverpool cruised.
Arsenal pulled off the result of the week in Dortmund while Barca, Chelsea and Napoli all scored three in victory.
Juventus earned a 2-2 draw with Real Madrid while Man City hit five and Man United found a spot of bother.
Manchester City smash seven past Norwich while Chelsea are humbled on Tyneside.
Luis Suarez scored a treble, as Man Utd left it late and Arsenal won again on the road.
Zlatan Ibrahimovic slammed home four goals, while Real beat Juve and there were wins for Bayern and both Manchester clubs.
Fernando Torres scored a brace on his 100th start as Chelsea won in Schalke, while Arsenal were beaten by Dortmund and Messi scored again for Barca.
Southampton claimed a point at Man United, while Arsenal, Chelsea and Man City all made no mistake.
Suarez and Sturridge scored as Liverpool went top, Manchester City bounced back, while a new Manchester United star was born.