Liverpool leapfrogged into second as Arsenal's season took another mighty blow and Chelsea marched on.
Man City lifted the Capital One Cup with a fine fightback against Sunderland.
Real Madrid thrashed Schalke 6-1 while Chelsea's reunion with Drogba ended in a 1-1 draw at Galatasaray.
Man Utd crashed to a 2-0 defeat at Olympiakos, while Dortmund claimed a convincing 4-2 victory at Zenit.
The top four in the Premier League, Chelsea, Arsenal, City and Liverpool, all won but it was not easy for some.
Arsenal and AC Milan will have it all to do after losing at home to Bayern Munich and Atletico Madrid.
Barcelona beat ten-man Manchester City, while PSG had Zlatan Ibrahimovic to thank in Leverkusen.
Arsenal reached the FA Cup quarterfinals with victory over Liverpool, while Everton saw off Swansea.
Manchester City beat Chelsea to reach the FA Cup quarterfinals while holders Wigan upset Cardiff.
Liverpool smashed five past Arsenal, while Man City drew another blank and allowed Chelsea to go top.
Chelsea stemmed the City flow; Liverpool were held at West Brom, while Alex Oxlade-Chamberlain fired the Gunners to victory over Palace.
Stoke sink Manchester United, while Hull hold Spurs and Everton beat Villa.
Man City came back from behind to beat Watford, both Mersey clubs won, as did Chelsea, but Palace crashed out.
Liverpool fought back for a point while Arsenal and Manchester City marched on.
Chelsea went top, as Tottenham and Everton both won and Man Utd eased the pressure.
Swansea dumped Man United out of the FA Cup while Chelsea and Liverpool eased into round four.