Daniel Luduena fired Santos Laguna into the last four of the Torneo Apertura as he struck the decisive goal to beat Jaguares 2-1 in their quarter-final second leg.
Luduena netted after 73 minutes to send his side through 4-3 on aggregate. Carlos Quintero had earlier opened the scoring for Santos on 41 minutes, and while Jackson Martinez equalised, Luduena sealed his side's progress.
Tigres Monterrey sealed their place in comfort as they thrashed 10-man Pachuca 3-0 to progress 4-0 on aggregate.
First-half goals from Manuel Viniegra, Lucas Lobos and Damian Alvarez killed off the tie before Pachuca had Hector Herrera sent off on 61 minutes.