Valencia climbed above city rivals Levante to third in the Primera Division thanks to a comfortable 2-0 victory in the derby.
Unfancied Levante had been top of the table before suffering their first league defeat away to Osasuna last weekend, a reverse that ended a seven-game winning run that included victory over Real Madrid.
As a result, Juan Ignacio Martinez's side headed into the Valencia derby ahead of their city rivals for the first time since 1964 and with a record of four wins from four games at Ciutat de Valencia.
However, Valencia were determined to reassert their authority and did so thanks to an own goal from Javi Venta and Tino Costa's free-kick, which also benefited from some assistance from the home side.
Real Betis ended their six-game losing streak with a creditable 0-0 draw at home to big-spending Malaga.
Betis gave as good as they got in a match that only showed signs of life in the second half and, while the hosts went goalless for a sixth game in seven, they could take solace in ending their losing slump.
Pepe Mel's side had their goalkeeper Casto the thank for the point though as he expertly kept out the best chance of the game on 55 minutes when Salomon Rondon headed on target from close range.
Defeat though would have been harsh on Betis as they also had their chances, most notably striker Alejandro Pozuelo, but worryingly again failed to find the net.
Sevilla goalkeeper Javi Varas was the hero as his side claimed a 0-0 draw at Real Mallorca.
Mallorca dominated the start of the second half but missed a host of great chances, with Alejandro Alfaro the main culprit. Sevilla then had their best period in the final ten minutes but created very little, with Dudu Aouate easily turning away their best effort through Jesus Navas.