Champions Ajax dropped their first points of the new Eredivisie season as they battled back from two goals down to grab a 2-2 draw at VVV-Venlo.
A second-half double from Ahmed Musa put VVV in charge and on course to inflict a first defeat of the season on the Amsterdammers.
But Ajax struck twice inside a minute to salvage a draw. Theo Janssen pulled a goal back in the 68th minute before Kolbeinn Sigthorsson levelled things up almost immediately.
AZ Alkmaar returned to winning ways by thumping 10-man NEC Nijmegen 4-0.
All of the goals arrived in the second half as Jozy Altidore bagged a brace, either side of a Rasmus Elm penalty, before captain Niklas Moisander completed the rout late on.
NEC's capitulation came after the dismissal of Pavel Cmovs for hacking down Maarten Martens after 63 minutes, which resulted in Elm's successful penalty.
PSV Eindhoven were also comfortable winners as they won 3-0 at ADO Den Haag.
First-half goals from Dries Mertens (21), Georgino Wijnaldum (24) and Ola Toivonen (39) made the points safe before the interval.
Guyon Fernandez struck a late equaliser to earn Feyenoord a 1-1 draw from their trip to Heracles Almelo.
Fernandez netted 12 minutes from time for the visitors to cancel out Glynor Plet's 63rd-minute opener for Heracles.