The Bundesliga returns after a fortnight off due to international matches, and there are several changes from the last time the 18 top-flight teams took to the field.
Schalke and Eintracht Frankfurt both have new coaches while Felix Magath prepares for his return to the VW-Arena for his second spell in charge of Wolfsburg.
Schalke's new coach Ralf Rangnick is also embarking on his second spell with the same club as he returns to Gelsenkirchen, but he has warned the fans not to expect miracles when they travel to St Pauli.
''I am excited to see how my players perform,'' he said. ''We want to go into the remainder of the season with a win. But it has to be clear that I cannot give the team a new way of playing in such a short time.''
Frankfurt have turned to Christoph Daum to save them from the threat of relegation and his first game back in the Bundesliga takes him to Wolfsburg on Sunday. However, he seems to be regretting his decision to replace Michael Skibbe.
''Negotiations with (Frankfurt president) Heribert Bruchhagen were incredibly positive and, in the end, I said that I would try to help Eintracht,'' he told the Frankfurter Allgemeine newspaper. ''I did not really realise how serious the situation was when Heribert came to me. I had not considered Eintracht at all before then, but when I started to consider it more, I realised how serious it was, but then I had already given my word.''
Frankfurt are currently just three points above the bottom three and four ahead of Wolfsburg.
St Pauli and Stuttgart are sandwiched between the two sides and the latter face a tricky trip to another struggler, Werder Bremen, on Saturday.
At the top of the table, league leaders Borussia Dortmund will be aiming to extend their seven-point lead over Bayer Leverkusen at the top of the table when they host Hannover, who also need the points to keep ahead of Bayern Munich in the race for a place in the Champions League.
Bayern are at home to bottom club Borussia Monchengladbach and they will expect three points at the Allianz Arena while Leverkusen will also be expecting to win at Kaiserslautern.
Elsewhere, Mainz host Freiburg with both sides still in the hunt for a place in the Europa League while, finally, Cologne host Nurnberg on Sunday.