Auxerre, Monaco and Valenciennes have all crashed out of the Coupe de France at the hands of lower-league opposition.
Injury-ravaged Auxerre went down 2-1 at amateur side Wasquehal.
The hosts scored twice in the final ten minutes, with Gregoire Debuchy's 80th-minute strike cancelling out Julien Quercia's opener before David Coulibaly won it from the penalty spot.
Monaco trailed early against another amateur side, Chambery, before the match finished in a 1-1 draw, Chris Malonga levelling after Thomas Dubard's opener, but the hosts prevailed 3-2 in a penalty shootout to go through.
Valenciennes finished with nine men as they went out in a 2-1 defeat to Ligue 2 side Angers.
The visitors had Gaetan Bong sent off after 43 minutes, but nevertheless led through a Karim Djellabi own goal just before the hour mark. However, Gaetan Charbonnier levelled and Claudiu Keseru won it in extra time before Vincent Aboubakar collected Valenciennes' second red card.
Romain Amalfitano got the goal as Ligue 2 Reims saw off Montpellier 1-0, while St Etienne crashed 2-0 at home against Clermont Foot, with the late dismissal of Laurent Batlles adding insult to injury.
Nice needed penalties to see off third-tier side Creteil after their match also finished in a 1-1 draw, Eric Mouloungui bringing them level after an early goal for the hosts.
Lille cruised to a 3-0 success over Forbach as Eden Hazard, Aurelien Chedjou and Gervinho all found the net.
Bordeaux also trailed early before beating Rouen 3-1 with a Anthony Modeste goal and a second-half brace from Cheick Diabete.
Pape Diakhate's 74th minute strike was enough for Lyon to win 1-0 at Caen, while Sochaux won 1-0 at Jarville thanks to an 82nd-minute strike from Ideye Brown.
Lorient came from behind to thrash Vannes 4-1 with goals from James Fanchone, Lynel Kitambala, Sigamary Diarra, and Fabien Robert.
Paris St Germain enjoyed a 5-1 thrashing of Lens, who finished the match with ten men.
Zoumana Camara and Nene already had PSG in a commanding position before Alaeddine Yahia was dismissed for the visitors. Guillaume Hoarau then added a brace, the first from the penalty spot, and Pegguy Luyindula wrapped up the PSG scoring before Eduardo scored a late penalty for Lens.
Also through to the next round are Le Mans, Nantes, Metz, Sedan, Nimes, Drancy, Quevilly, and Cherbourg.