Roy Hodgson was left reeling after Liverpool suffered a dramatic late 2-1 defeat at Tottenham as well as losing Jamie Carragher to injury.
Carragher had to be withdrawn late in the game and, with Steven Gerrard already sidelined with a hamstring injury, it is another significant blow for the Reds.
"We think Jamie has dislocated his shoulder which is a real blow for us and for him," Hodgson said. "I don't know at this stage how long Jamie will be out for but I would think it will be quite long because it's a serious injury.
"It is a blow for us. Agger is still out injured and we are not really that well blessed for centre-halves. We are now without Steven Gerrard and Jamie for a period of time, both of whom are the lifeblood of this club."
Liverpool had been on course for victory after Martin Skrtel's effort shortly before the break but, after Jermain Defoe missed a disputed penalty, Skrtel turned the ball into his own net on 65 minutes and Aaron Lennon got the winner in injury time.
"I'm very disappointed because I didn't feel we deserved to lose this game," Hodgson said. "It was especially disappointing because it came at a time when we had to reorganise our defence when Jamie Carragher had to leave the field.
"It seemed to be a cruel way to come away from a game where we played well only to end up with nothing and losing our talismanic centre-half.
"We then paid the price for not dealing with a very simple long ball which caught us unaware and Lennon then used his pace and sneaked in to score the winning goal.
"I'm finding it hard to come to terms with the fact we have got nothing out of this game, but the result is not going to change with me being disappointed.
"We had plenty of chances in the game and we played well enough to have put this game to bed before half-time and then just after the interval, but we didn't do so and then you always run the risk of the other team getting themselves back into it.
"Tottenham are a very good attacking team and they certainly asked lots of questions of us, but I thought we asked plenty of questions of them as well."
Spurs boss Harry Redknapp praised Liverpool but felt his side had grown stronger as the game wore on.
"They started well and were dangerous," he said. "It was a fantastic game.
"Liverpool played their part - they were always a threat. They had opportunities to score again, they had good chances, we became disorganised, but we got after them a bit better, had shots blocked, missed a penalty and eventually managed to get the goal.
"We had lots of good chances and, in the end, I felt we deserved the win. It was a great performance to come from one down."
He added: "We're not a team that you can write off and go, 'They're going nowhere, are they?'
"Even if you're one down, we're always going to make plenty of opportunities and it's a case of sticking them away. I just feel we've got a belief in there that we can come from behind."