Netherlands forward Dirk Kuyt, who made a comeback from a shoulder injury at the weekend, is set to face his former club.
"It means a lot to go back," Kuyt told the club's official website. "They are the club that gave me the opportunity to play professional football. I had five years there and really enjoyed it. I was really happy for the opportunity they gave me.
"I don't know a lot of players there now. There are just two or three that still play for the team, but I also know a few guys who work at the club so it'll be nice to go back and see them."
He added: "We want to get a result. If we beat Utrecht in Utrecht, it will be great because we would have six points in the group already and we would almost be in the next round.
"We work every day with this team and know we have the quality. It's just a matter of time until we get results."