Wolves midfielder Adlene Guedioura could be out for up to six months after fracturing his tibia in Sunday's Premier League defeat to Aston Villa.
Guedioura sustained the injury in the closing stages of the 2-1 loss following a challenge from Villa midfielder Steve Sidwell.
"It's desperately disappointing news both for Adlene and the club,'' said Wolves boss Mick McCarthy.
"It is going to be a lengthy absence but on the plus side the consultant has told us it's an uncomplicated fracture,'' Steve Kemp, Head of Wolves' medical department, told the club's official website. "In these situations that's as good as it gets.
"Adlene will be in a full leg non weight-bearing cast for four weeks before progressing to a partial weight-bearing cast after that.''
Guedioura joined Wolves on a permanent basis in the summer following a successful spell on loan from Charleroi.
This season he started both Carling Cup victories while coming off the bench in four of the six Premier League fixtures played so far.