Lille claimed local bragging rights in emphatic style with a 4-0 thrashing of Valenciennes on Saturday.
Lille coach Rudi Garcia had stressed the importance of the 'derby' clash - the clubs are 32 miles apart - and goals from Pierre-Alain Frau and Yohan Cabaye either side of a Gervinho brace lifted Lille to 13th in the table.
Lowly Paris St Germain ended Auxerre's surprise Ligue 1 run by beating the leaders 1-0 at Parc des Princes.
Midfielder Jeremy Clement headed home a cross by Brazilian defender Ceara on 67 minutes to give PSG the points and move the capital club up a spot to 12th in the 20-strong league.
Lens made it three wins in succession with a dramatic 93rd-minute winner against Marseille. Eduardo dos Santos headed home deep in stoppage time to give Lens all three points and deliver a further blow to Marseille's title hopes.
Lorient moved into second place, also a point off the lead, after needing a goal in added time from forward Kevin Gameiro to salvage a 2-2 home draw with bottom club Grenoble, still without a win after 14 games.
Mohamed Fofana's first-half goal was enough for Toulouse to get back to winning ways with a 1-0 win over Boulogne.
Les Violets saw a four-match unbeaten run ended by Nice last Sunday, but had the better of the game against Laurent Guyot's strugglers.
Sochaux pulled off a wholly undeserved 1-0 win over southerners Nice as a controversial goal decided a game in which the visitors dominated.
After being largely outclassed in the opening stages, Sochaux went in front in the 28th minute as Yassin Mikari's shot hit the bar, bounced down and then out with the referee awarding the goal
Montpellier's squad has been hit by the H1N1 flu virus, forcing their Ligue 1 game at Monaco scheduled for Saturday to be postponed. No new date has yet been set.