Eredivisie leaders FC Twente wrapped up their 10th win of the season with 2-1 victory over Roda JC.
Two goals in the space of seven first-half minutes from Bryan Ruiz and Miroslav Stoch put the visitors in control, but they had to endure a nervy finish after Jeanvion Yulu-Matondo put the hosts back in it 11 minutes after the break.
Balazs Dzsudzsak's fifth league goal of the season settled a low-key encounter at Phillips Stadion as PSV Eindhoven beat Vitesse 1-0. The Hungary international pounced on defensive uncertainty to slot the ball past keeper Piet Velthuizen in the second half.
PSV were dominant throughout, and could have extended their lead but for a late double save by Velthuizen which denied Jonathan Reis a second goal.
Eredivisie champions AZ Alkmaar's struggles continued as they needed a late goal from Jeremain Lens to see off lowly FC Groningen. AZ went into the match having won only one of their last six league games while Groningen were fresh from a 5-1 cup thrashing of Vitesse Arnhem in midweek.
Heerenveen gave themselves a much-needed boost with a comfortable home win over 10-man ADO Den Haag. Roy Beerens' first-half opener gave the home side the lead before Pascal Bosschaart was sent off before half-time, and Michal Papadopulos' second-half brace secured the win.