Unibond League side Curzon Ashton survived a late scare to knock their League Two opponents Exeter City out of the FA Cup with a 3-2 first round win.
Currently lying 12th in the non-league league, the hosts defied the 77 league places that separate the two sides to cruise into a 3-0 lead.
They opened the scoring through midfielder Chris Worsley who fired past Paul Jones in the Exeter goal from just inside the area after 25 minutes.
James Ogoo doubled the hosts' advantage 10 minutes into the second half when he picked up a loose ball to hammer home from long range.
Michael Norton scored the hosts' third before Steve Basham and Dean Moxey hit back for Exeter to ensure a nail-biting end for the home fans.
Curzon Ashton held on, however, to secure their passage to the second round.
Shrewsbury were another League Two side who were humbled by non-league opposition as they lost 3-1 at Blue Square North's Blyth Spartans.
Shaun Reay got the hosts off to the perfect start when he opened the scoring after just 31 seconds when he curled a shot past Glyn Garner in the Shrewsbury net.
Andrew Wright doubled the hosts' advantage on 28 minutes when he drilled home through a crowded penalty area before Simon Todd hit Spartans' third.
Grant Holt headed home from a Paul Murray cross to pull one back for Shrewsbury but Spartans go into the hat for the second round of the cup.
Daniel Wright grabbed the only goal of the game at the Glass World stadium where non-league Histon shocked League One Swindon with a 1-0 win.
The striker smashed home Lanre Oyebanjo's corner after 66 minutes to give the Blue Square Premier side the lead.
Histon goalkeeper Danny Naisbitt was kept busy as Swindon looked for an equaliser, pulling off saves from Barry Corr and Jon-Paul McGovern to ensure Histon's passage to the second round.
Gary Madine saved managerless Carlisle United's blushes as they drew 1-1 with Blue Square Premier side Grays Athletic at Brunton Park.
The second-half substitute poked home from close range with six minutes left after Jamie Stuart had given Grays the lead with a well-taken volley seven minutes into the second half.
Jean Francois Christophe's last-gasp equaliser denied AFC Telford a win over League One Southend at the New Bucks Head Stadium.
The Blue Square North side went behind just after the half-hour when Francis Laurent struck from just inside the box after some good work by Christophe.
A second-half double from Jon Adams had the home side's supporters dreaming of victory but Christophe's long-range effort one minute into added time earned Southend a 2-2 draw and a replay.
Port Vale came back from 3-1 down to stun Huddersfield in a seven-goal thriller at the Galpharm Stadium.
Louis Dodds gave Vale the lead after 26 minutes but the hosts hit back to open up a two-goal advantage thanks to goals from Michael Collins, Ian Craney and Robbie Williams.
A David Howland strike and a second from Dodds levelled the scores before Marc Richards hammered his free-kick past Matthew Glennon in the first minute of injury time to book Vale's place in the second round.
Blue Square Premier side Droylsden earned a replay with Darlington after playing out a goalless draw with the League Two leaders at the Darlington Arena.
Bradford's Graeme Lee scored a late free-kick to shock League One high-flyers MK Dons at Stadium MK.
The Bantams opened the scoring in the first minute through Omar Daley but were pegged back by a Jemal Johnson strike just before half-time.
Lee's low drive 10 minutes from time, however, sent Roberto Di Matteo's side out of the cup at the first hurdle.