Two former FA Cup final stars come face-to-face as managers in the first round when Milton Keynes Dons host Bradford.
Dons boss Roberto Di Matteo scored the fastest goal in a Wembley cup final when his 30-yard effort set Chelsea up for a 2-0 victory over Middlesbrough in 1997.
And Bradford manager Stuart McCall hit both goals in Everton`s 3-2 defeat to Liverpool in the second all-Merseyside final in 1989.
Di Matteo will experience his first taste of FA Cup action from the touchline and he is looking forward to it.
"It's great because it moves the whole country. It's not like other competitions - from non-league upwards, everyone is involved,'' the Italian said. "For me it's nice because I've got some fond memories but I think all the players value the FA Cup. It has so much history and people just go crazy for it.
"Smaller teams can beat the bigger teams; teams they would never be able to play against otherwise.''
MK Dons, who are currently fourth in League One, naturally start the match as favourites, although the Bantams are riding high in third in League Two.
"MK Dons are on a terrific run and they are formidable at home. We don't want to go down there and be lambs to the slaughter,'' McCall told the Telegraph and Argus.
"If we defend as poorly as we did last week (in a 3-3 draw with Barnet), then we'll be in trouble, but who knows with cup football and we'll give it a go.''
There are 16 all-Football League ties but of the others Blue Square Premier side Histon will be looking to maintain their recent good record - having reached the second round four times in the last five years - against League One Swindon.
"We've got everything going for us at the moment and it's a game ahead of which every single person at this club - players and supporters - thinks we can cause an upset,'' Histon manager Steve Fallon told BBC Radio Cambridgeshire.
Swindon boss Maurice Malpas is determined to ensure his side do not slip up.
"It is a game we are taking very seriously,'' the former Motherwell boss said on the club's website, swindontownfc.co.uk.
"We know all about them having had them watched last weekend and I went to see them against Hinckley earlier in the week. It will be a physical encounter but the players know what is waiting for them.
"I get a buzz from the cup competitions. However, the one thing we don't want to do is go to Histon and lose the game. Hopefully we can get the job done at the first time of asking.''
Other non-league sides looking to cause an upset include Blyth Spartans, at home to League Two Shrewsbury, Curzon Ashton, hosting Exeter, Grays Athletic at Carlisle and Droylsden at Darlington.