Roma and Atletico Madrid face English opposition in the Champions League on Wednesday night as they look to exorcise their demons after painful defeats in league action at the weekend.
Italian outfit Roma travel to Stamford Bridge to take on in-form Chelsea after being beaten 4-0 at home by Inter Milan on Sunday. The result has cast doubt on the future of coach Luciano Spalletti after the club's indifferent start to the season which sees them in 14th position in Serie A.
After two games, Roma are third in Group A following an embarrassing 2-1 home defeat to newcomers CFR Cluj and 3-1 away win over French side Girondins Bordeaux, who play host to Cluj on Wednesday.
Having lost 2-1 at home to bitter city rivals Real on Saturday, a third consecutive La Liga defeat, Atletico Madrid face Liverpool at the Vicente Calderon stadium.
Madrid coach Javier Aguirre could ease the pressure with an immediate reaction against a Liverpool team playing well in domestic football, but who are shorn of former Atletico star Fernando Torres - who misses out on a playing return because of injury.
A win for either side would put them in a strong position in Group D, with both having won their first two matches against PSV Eindhoven and Olympique Marseille.
Elsewhere in Wednesday's Champions League action, Jose Mourinho's Inter host Group B's surprise joint leaders Anorthosis Famagusta, while Werder Bremen visit winless Panathinaikos.
In Group C, Sporting Lisbon are away to Shakhtar Donetsk, while leaders Barcelona travel to bottom side Basel and will expect to maintain their 100% record in the competition this season which stretches back to the third qualifying round in August.