Arsenal striker Robin van Persie has withdrawn from the Holland squad for the upcoming World Cup qualifier against Iceland.
The 25-year-old is suffering from a hamstring injury and will play no part in Saturday's game, but will be reassessed ahead of Wednesday's visit to Norway.
It is the latest blow for Holland coach Bert van Marwijk, who has already seen Real Madrid winger Arjen Robben and Celtic striker Jan Vennegoor of Hesselink withdraw from the squad.
And with Atletico Madrid defender John Heitinga nursing a knee injury, Van Marwijk has called up Jan Kromkamp of PSV Eindhoven as cover.
Kromkamp has played 11 times for Holland but has not featured competitively for the Oranje for two years.