Goias moved up to ninth in the Campeonato Brasileiro after ending Santos' six-match unbeaten run with an emphatic 4-1 win on Saturday.
The hosts enjoyed an excellent start with three goals in the first 14 minutes.
Paulo Baier fired Goias ahead after only a minute and Anderson Gomes added a second three minutes later before former Boca Juniors forward Pedro Iarley added a third from the penalty spot.
Rafael Marques extended the lead eight minutes into the second half before Para netted a 75th minute consolation for Santos.
Santos remained in 13th place after their first loss in seven games.
"This was a bad result for us but we now have two games at home to recover from this match and we can't afford to fail," said Santos defender Fabiano Eller.
Fluminense remained in the relegation zone after a 3-2 home loss to Coritiba.
Carlinhos Paraiba opened the scoring for the visitors after 10 minute, but a brace by Washington sent the hosts into the half-time break 2-1 up.
But Kerrison levelled the score 12 minutes into the second half and grabbed his second 18 minutes from time to send Coritiba up to seventh.
Atletico Mineiro came from a goal down to defeat Nautico 2-1.
The Recife side went ahead through Ruy after 18 minutes but Renan Oliveira equalised just before the interval and Vinicius netted the winner for the hosts midway through the second half.